“Let food be the medicine and medicine be your food” (Hippocrates of Cos "Ancient Medicine ", ca 460 BC - 377 BC terminus ante quem) Since time immemorial, food, as well as food, are considered active substances that may cause harm or benefit depending on how they are associated with or utilized. The interaction between the food and drugs is, however, still an aspect of cli- nical little considered and sometimes misunderstood, identifying, erroneously, mostly the symptomatology that comes as a secondary effect resulting only from the active principle of the drug, although the relationship between drug administration and power is well codified and strictly recommended in all sheets, indirectly confirming the close relationship between the two active in- gredients. The intake of food and beverages can affect the action of drugs, not only by changing the absorption but also by interfering directly with the biochemical mechanisms of activation and degradation, reducing their effectiveness or in- creasing its toxicity. The same mechanism of interference can occur between different foods if they are taken simultaneously, to confirmation of what the food cleaved with digestion in the first substances is actually a real operatio- nal workshop. In confirmation of what is increasingly the emerging importance of the interfe- rence drugs - the same food Food and Drug Administration (FDA) has publis- hed a guide on the possible interactions (1). Increasingly emerge recommen- dations on a punctual control of the labels of food and drinks not only to check the quality but also the content of active substances, such as caffeine. Great strides have been made in recent years mainly due to the evaluation of the side effects associated with new oral anticancer drugs and biologics, iden- tifying the most significant interactions involving the cytochrome p450 family and in particular of a reversible inhibitor of CYP3A4 and CYP2E1. The new concept of the presence of components of "nutraceuticals", in the nor- mal consumption of foods that can become a way to achieve physical and men- tal wellbeing, or even prevent / combat various diseases through nutrition. Identifying the mechanisms underlying the protective / preventive and analysis of these components benefit / risk is one of the main challenges for the future of research in biochemistry and toxicology. The purpose of this conference is to analyze some general concepts of pharmacology deepening drug - food interaction and its implications on the absorption distribution transformation bioavailability and thus the efficacy and toxicity of drugs.
Dr. Fulvia Pedani Scientific Director of the Meeting