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Genetics is often associated with the term “revolution”, indicating the extraordinary transformation had by this discipline in recent years. The most radical changes were marked by the technological revolution that made it possible to raise progressively the resolution of genetic investigations, reducing costs and time of the analysis and therefore the knowledge to larger and larger segments of the population. Genomics, the study of the genome, can be considered the most advanced field of genetics, for the ability to identify individual differences that can explain a significant part of the state of health and disease. For these reasons, knowledge mediated by recent developments in this discipline must be governed, made accessible and integrated in health plans.

The Human Genome Project has opened new horizons setting the stage for the “genomic medicine” and has led to fundamental advances in understanding the molecular and cellular mechanisms of diseases, which have given way to new diagnostic and therapeutic approaches for early prediction, diagnosis and prevention of many Mendelian and common diseases.

The genomic approach is an entirely new way of practicing medicine both at the bedside and in the organization of public health. It is playing an increasingly important role in clinical practice, partly thanks to rapid technological progress that allows a technique more and more refined in the face of a rapid reduction of time and costs. A growing number of guidelines suggests including molecular genetic tests for the diagnosis and treatment of monogenic and complex diseases in greater social impact such as tumors, neurodegenerative, metabolic and cardiovascular diseases. Public health is dealing with guidelines that properly directs towards a personalized therapy and which also corresponds to the drug economy criteria.

The new methodologies - capable of distinguishing the contribution of the many factors that contribute to genome-environment interaction which determine the phenotype of an individual - can really change our future? Does the genomic approach - able to distinguish the contribution of genetics, socio-cultural conditions, lifestyles and more generally of the environmental factors contributing to diseases, especially chronic ones and infectious - will modify medicine?

This meeting is intended to make the state on the latest conceptual and technological achievements in this field of biomedical research and consider their application in clinical practice, as well as the psychological, ethical and legal implications that the prediction and understanding of mechanisms of health and disease can create by defining an individual’s risk of contracting certain diseases.

 

The major international experts will delve into the current knowledge about:

  • Epigenetics and epigenomics
  • Personalized or Precision Medicine
  • Genomics and prevention of greater social impact diseases
  • How genomics will change the diagnosis and treatment of cancers, cardio vascular and neurological diseases
  • pharmacogenomics
  • New molecules and target therapy
  • Genome editing and gene therapy

Antonio Amoroso
President of the Meeting

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